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Although the presented B. The online version of this article doi The broad-spectrum antibiotic erythromycin, produced by the actinomycete Saccharopolyspora erythraeais a well-studied representative of a class of complex natural products called polyketides Corcoran Its macrolide core, 6-deoxyerythronolide B 6dEBis synthesized by a polyketide synthase PKS that has emerged as the prototypical modular megasynthase Khosla et al.

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